I-CAS 62-44-2 Phenacetin Ukuxhasa iindlela ezahlukeneyo zokuhlawula

I-CAS 62-44-2 Phenacetin Inkxaso yeendlela ezahlukeneyo zokuhlawula Umfanekiso obonakalisiweyo

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62-44-2

Igama eliqhelekileyo	Phenacetin
Inombolo yeCAS	62-44-2	Ubunzima beMolekyuli	179.216
Ukuxinana	1.0±0.1 g/cm3	Indawo yokubilisa	323.6±44.0 °C kwi-760 mmHg
Ifomula yeemolekyuli	C₁₀H₁₃NO₂	Indawo yokunyibilika	133-136 °C(lit.)
I-MSDS	IsiTshayina i-USA	Indawo yokuflasha	149.5±28.4 °C
Uphawu	GHS07, GHS08	Igama loMqondiso	Ingozi

62-44-2 (5)

62-44-2 (4)

62-44-2 (3)

62-44-2 (2)

62-44-2 (1)
ukupakisha (4) ukupakisha (2)

Ukusetyenziswa kwePhenacetin

I-Phenacetin i-analgesic engeyona i-opioid ngaphandle kweempawu ezichasayo, inqanda umsebenzi we-COX-3.Injongo: I-COXPhenacetin iyisilwanyana esinciphisa intlungu kunye nokunciphisa umkhuhlane, i-Phenacetin yahoxiswa kwimarike yaseCanada ngoJuni 1973 ngenxa yeenkxalabo malunga ne-nephropathy.idatha yeklinikhi kunye nelabhoratri yayihambelana ne "phenacetin nephritis" njengoko ichazwe eYurophu nase-Australia kwaye kutshanje e-United States naseKhanada.Le ngxelo ivavanya iziphumo kwiimeko ze-23 kunye nezilumkiso malunga nokusetyenziswa kwe-phenacetin, ngokukodwa kwizigulane ezinokukhubazeka kwe-renal [1].I-Phenacetin iye yadibaniswa ne-renal papillary necrosis ebantwini [2, 3].

Phenacetin Biological Activity

Inkcazo

Ikhathalogu enxulumeneyo

Iindawo zoPhando >> Ukudumba/I-Immunology

Ekujoliswe kuko

I-COX-3:102 μM (IC50)

Isinyibilikisi

I-In vitro:

10 mM kwi-DMSO

Ukunyibilika

1 mM	5.5797 mL	27.8987 ml	55.7973 mL
5 mM	1.1159 mL	5.5797 mL	11.1595 mL
10 mM	0.5580 mL	2.7899 mL	5.5797 mL

Ugcino

Umgubo	-20°C	Iminyaka emi-3
	4°C	iminyaka eyi-2
Kwi-solvent	-80°C	Iinyanga ezi-6
	-20°C	Inyanga eyi-1

Ukuhambisa ngenqanawe

Ubushushu begumbi kwilizwekazi lase-US;zinokwahluka kwenye indawo

UNCUMILE

CC(NC1=CC=C(OCC)C=C1)=O

Iimbekiselo

[1].Chandrasekharan NV, et al.I-COX-3, i-cyclooxygenase-1 i-variant inhibited yi-acetaminophen kunye nezinye izidakamizwa ze-analgesic / antipyretic: i-cloning, isakhiwo, kunye nokubonakalisa.Proc Natl Acad Sci US A. 2002 Oct 15; 99 (21): 13926-31 [2].Brix, AE, Renal papillary necrosis.I-Toxicol Pathol, 2002. 30 (6): iphe.672-4.

[3].Dubach, UC, B. Rosner, kunye noT. Sturmer, Uphononongo lwe-epidemiologic lokusetyenziswa kakubi kweziyobisi ze-analgesic.Iziphumo ze-phenacetin kunye ne-salicylate ekufeni kunye ne-cardiovascular morbidity (1968 ukuya kwi-1987).N Engl J Med, 1991. 324(3): iphe.155-60.

Iimolekyuli ezinxulumeneyo

Izithethantonye

MFCD00009094
I-Acetamide, N-(4-ethoxyphenyl)- (9CI)
N-(4-ethoxyphenyl) -acetamide
I-P-PHENACETIN
Ethanimidic acid, N-(4-ethoxyphenyl)-, (1E)-
Achrocidin
p-ethoxyacetanilide
phenacetin
Iphenacetine
phenacitin
Codempiral
Acetphenetidin
I-ACETOPHENETIDIN
Contradouleur
Acetophenetidine
I-Fenacetina
Acetophenetin
N-(4-Ethoxyphenyl)acetamide
(1E)-N-(4-Ethoxyphenyl)ethanimidic acid
I-N-acetyl-p-phenetidine
p-Acetophenetidide
IAcetamide, N-(4-ethoxyphenyl)-
N-(4-ethoxyphenol)i-acetamide
IAcetamide, N-(4-ethoxyphenol)-
I-Aceto-p-phenetidin
I-EINECS 200-533-0
4'-ethoxyacetanilide
N-[4-(ethyloxy)phenyl]acetamide
N-Acetyl-para-phenetidine
I-Acetanilide, 4'-ethoxy-
N-Acetyl-4-ethoxyaniline

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