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Igama eliqhelekileyo	Xylazine
Inombolo yeCAS	7361-61-7	Ubunzima beMolekyuli	220.334
Ukuxinana	1.2±0.1 g/cm3	Indawo yokubilisa	334.2±52.0 °C kwi-760 mmHg
Ifomula yeemolekyuli	C₁₂H₁₆N₂S	Indawo yokunyibilika	140ºC
I-MSDS	IsiTshayina i-USA	Indawo yokuflasha	155.9±30.7 °C
Uphawu	GHS06	Igama loMqondiso	Ingozi

7361-61-7 (3) 7361-61-7 (2) 7361-61-7 (1) ukupakisha (7) ukupakisha (6)

Ukusetyenziswa kweXylazine

I-Xylazine yi-α2 iklasi ye-adrenergic receptor agonist.Ithagethi: I-Adrenergic ReceptorXylazine sisiyobisi esisetyenziselwa ukutshatyalaliswa, i-anesthesia, ukuphumla kwemisipha, kunye ne-analgesia kwizilwanyana ezifana namahashe, iinkomo kunye nezinye izilwanyana ezingezona abantu.I-analogue ye-clonidine, i-agonist kwiklasi ye-α2 ye-adrenergic receptor.I-Xylazine isanda kuvela njengeyeza lokuzonwabisa, ngakumbi ePuerto Rico [1].Ukulawulwa kwe-xylazine (i-0.17 mg / kg yesisindo somzimba, ihlanjululwe kumthamo we-10-ml, usebenzisa i-0.9% ye-NaCl) yenza malunga neeyure ze-2.5 ze-analgesia yendawo ngaphandle kwemiphumo ebonakalayo.Amanani aphezulu e-xylazine abangela i-ataxia yomlenze ongasemva.Ukulawulwa kwe-lidocaine kubangele ixesha elifanayo le-analgesia, kunye ne-ataxia yangemva enzima (i-100% izehlo).Siye sagqiba kwelokuba i-xylazine enikwe ngenaliti ye-epidural iphumela ekukhuselekeni, okusebenzayo kwe-perineal analgesia kumahashe [2].

Xylazine Biological Activity

Inkcazo

Ikhathalogu enxulumeneyo

Iindlela zoMqondiso >> GPCR/G Protein >> I-Adrenergic Receptor

Iindawo zoPhando >> Izifo zeNeurological

Isinyibilikisi

I-In vitro:

10 mM kwi-DMSO

Ukunyibilika

1 mM	4.5386 mL	22.6932 mL	45.3865 mL
5 mM	0.9077 ml	4.5386 mL	9.0773 mL
10 mM	0.4539 mL	2.2693 mL	4.5386 mL

Ugcino

Nceda ugcine imveliso phantsi kweemeko ezicetyiswayo kwiSatifikethi sokuHlalutya.

Ukuhambisa ngenqanawe

Ubushushu begumbi kwilizwekazi lase-US;zinokwahluka kwenye indawo

UNCUMILE

CC1=C(C(C)=CC=C1)NC2=NCCCS2

Iimbekiselo

[1].Reyes, JC, et al., Ukuvela kwe-xylazine njengesiyobisi esitsha sokusetyenziswa kakubi kunye nemiphumo yempilo phakathi kwabasebenzisi beziyobisi ePuerto Rico.J Urban Health, 2012. 89(3): p.519-26.

[2].I-Hsu, i-WH, i-Xylazine-induced depression kunye ne-antagonism yayo yi-alpha adrenergic blocking agents.J Pharmacol Exp Ther, 1981. 218(1): iphe.188-92.

Iimolekyuli ezinxulumeneyo

Ulwazi lweToxicological

UKUFUMANA KWEKHEMIKHALI

RTECS INOMBOLO :: XJ0776300

IGAMA LEKHEMIKALI :: 4H-1,3-Thiazine, 5,6-dihydro-2- (2,6-xylidino)-

INOMBOLO YOBHALISO LWE-CAS :: 7361-61-7

UKUHLAZIYWA KOKUGQIBELA :: 199606

IINGCACISO YEDATHA :: 8

IFOMU YEMOLEKULULA :: I-C12-H16-N2-S

Ubunzima bemolekyuli :: 220.36

WISWESSER LINE INGCACISO :: T6N CS AUTJ BMR B1 F1

IDATHA YENGOZI YEMPILO

IDATHA YEXHOXUBU EYENZIWAYO

UHLOBO LOVAVANYO :: I-TDLo - Idosi enetyhefu epapashiweyo ephantsi

INDLELA YOKUVEZA :: Ngomlomo

IINDIDI EZIQWALASELWEYO :: Umntu - umfazi

ITHAMO/UBUDE :: 8 mg/kg

IZIPHUMO EZIYItyhefu :: Ukuziphatha - ukulala (umsebenzi wokudakumba jikelele) Ukuziphatha - utshintsho kumsebenzi wemoto (uvavanyo olukhethekileyo) Intliziyo - izinga lokubetha kwentliziyo

ISIQINISEKISO :: CTOXAO Clinical Toxicology.(eNew York, NY) V.1-18, 1968-81.Ngolwazi lompapashi, bona i-JTCTDW.Umqulu(umcimbi)/iphepha/unyaka: 18,663,1981

UHLOBO LOVAVANYO :: I-TDLo - Idosi enetyhefu epapashiweyo ephantsi

INDLELA YOKUVEZA :: I-Intramuscular

IINDIDI EZIQWALASELWEYO :: Umntu - umfazi

ITHAMO/UBUDE :: 734 ug/kg

IZIPHUMO EZIYItyhefu :: Amalungu oMvo kunye neeMvo eziKhethekileyo (Iliso) - i-miosis (ukuphazamiseka komfundi) Intliziyo - isantya se-pulse I-Vascular - Ukunciphisa i-BP ayibonakali kwicandelo lokuzimela

ISIQINISEKISO :: I-AJEMEN i-American Journal ye-Emergency Medicine.(WB Saunders, Philadelphia, PA) V.1- 1983- Umqulu (umcimbi)/page/year: 4,222,1986

UHLOBO LOVAVANYO :: I-TDLo - Idosi enetyhefu epapashiweyo ephantsi

INDLELA YOKUVEZA :: I-Intramuscular

IINDIDI EZIQWALASELWEYO :: Umntu - umfazi

ITHAMO/UBUDE :: 22 mg/kg

IZIPHUMO EZIYItyhefu :: Ukuziphatha - ukulala (uxinzelelo jikelele) Intliziyo - izinga lokubetha kwemiphunga, iThorax, okanye ukuphefumla - ukutyeba kwepleural

ISIQINISEKISO :: I-AJEMEN i-American Journal ye-Emergency Medicine.(WB Saunders, Philadelphia, PA) V.1- 1983- Umqulu (umcimbi)/page/year: 4,222,1986

UHLOBO LOVAVANYO :: I-LD50 - i-Lethal dose, i-50 ekhulwini ibulala

INDLELA YOKUVEZA :: Ngomlomo

IINDIDI EZIQWALASELWEYO :: Impuku - impuku

ITHAMO/UBUDE :: 130 mg/kg

IZIPHUMO EZIYItyhefu :: Iinkcukacha zeziphumo eziyityhefu ezingaxelwanga ngaphandle kwexabiso lethamo elibulalayo

ISIQINISEKISO :: DTTIAF Deutsche Tieraerztliche Wochenschrift.(Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.Umqulu(umcimbi)/iphepha/unyaka: 75,565,1968

UHLOBO LOVAVANYO :: I-LD50 - i-Lethal dose, i-50 ekhulwini ibulala

INDLELA YOKUVEZA :: Ngomlomo

IINDIDI EZIQWALASELWEYO :: Impuku - impuku

ITHAMO/UBUDE :: 240 mg/kg

IZIPHUMO EZIYItyhefu :: Iinkcukacha zeziphumo eziyityhefu ezingaxelwanga ngaphandle kwexabiso lethamo elibulalayo

ISIQINISEKISO :: DTTIAF Deutsche Tieraerztliche Wochenschrift.(Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.Umqulu(umcimbi)/iphepha/unyaka: 75,565,1968

UHLOBO LOVAVANYO :: I-LD50 - i-Lethal dose, i-50 ekhulwini ibulala

INDLELA YOKUVEZA :: I-subcutaneous

IINDIDI EZIQWALASELWEYO :: Impuku - impuku

ITHAMO/UBUDE :: 121 mg/kg

IZIPHUMO EZIYItyhefu :: Iinkcukacha zeziphumo eziyityhefu ezingaxelwanga ngaphandle kwexabiso lethamo elibulalayo

ISIQINISEKISO :: DTTIAF Deutsche Tieraerztliche Wochenschrift.(Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.Umqulu(umcimbi)/iphepha/unyaka: 75,565,1968

UHLOBO LOVAVANYO :: I-LD50 - i-Lethal dose, i-50 ekhulwini ibulala

INDLELA YOKUVEZA :: Ngemithambo

IINDIDI EZIQWALASELWEYO :: Impuku - impuku

ITHAMO/UBUDE :: 18 mg/kg

IZIPHUMO EZIYItyhefu :: Iinkcukacha zeziphumo eziyityhefu ezingaxelwanga ngaphandle kwexabiso lethamo elibulalayo

ISIQINISEKISO :: I-CSLNX* UPhando lweSixhobo soMkhosi wase-US kunye noMyalelo woPhuhliso, iLebhu yeeNkqubo zeMichiza, i-NIOSH yoTshintsho lweMichiza.(I-Aberdeen Proving Ground, MD 21010) Umqulu(umcimbi)/iphepha/unyaka: NX#10054 *** UPHUHLISO LWEMIGANGATHO YE-NIOSH KUNYE NOLWAZISO LOPHONO - E0475 Inani leZibonelelo: 403 (uqikelelo) Nombolo yaMashishini: 1 Inani leMisebenzi: 5 Inani labaqeshwa: 4029 (iqikelelo) Inani labaqeshwa ababhinqileyo: 2015 (iqikelelo)

Izithethantonye

Rompun

Xylazinum

ixylazine

MFCD00057908

Xilazina [INN-Spanish]

I-EINECS 230-902-1

4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl) -5,6-dihydro-

UNII-2KFG9TP5V8

N-(2,6-Dimethylphenyl) -5,6-dihydro-4H-1,3-thiazin-2-amine

Xylazinum [INN-Latin]

Xylazin

Xilazina

(5,6-dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-amine

Inkampani yethu

I-Wuhan Xiju Biotechnology Co., Ltd. ngumvelisi oqeqeshiweyo wenkqubo ephakathi yamayeza.Inkampani inophando oluzimeleyo kunye neqela lophuhliso, elinokuthi liphande kwaye liphuhlise naziphi na izinto eziluhlaza zonyango, ngexabiso eliphantsi, umgangatho ophezulu kunye nenkonzo yeklasi yokuqala!

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Ngaphambili: I-CAS 23076-35-9 i-hydrochloride

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